32.1.183 OperationalDepletion

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\( y=B+\frac{E_m-B}{1+(op)^n}\)

\(where \ op = \frac{K_a+x}{T_{au}\cdot x}\)

Brief Description

Operational model for receptor depletion when X is concentration or dose.

Sample Curve

Parameters

Number: 5

Names:Em, B, Ka, Tau, n

Meanings: Em=maximum possible system response, B=response without agonist, Ka=agonist-receptor dissociation constant, Tau=dissociation constant, n=transducer ratio

Lower Bounds: none

Upper Bounds: none

Derived Parameters

logTau=log(Tau)

logKa=log(Ka)

Script Access

nlf_OperationalDepletion(x,Em,B,Ka,Tau,n)

Function File

OperationalDepletion.fdf