32.1.178 OneSiteCompFitKi

Function

\( logx_{0} = \log\left(10^{logKi} \cdot \left(1+\frac{H_{1}}{H_{2}}\right)\right)\)
\(y = A_2 + \frac{A_1-A_2}{1+10^{\left(x-\log x_{0}\right) }}\)

Brief Description

One Site Competition curve. Dose-response curve with Hill slope equal to -1.

Sample Curve

Parameters

Number: 5

Names: A1, A2, logKi, H1, H2

Meanings: A1=top asymptote, A2=bottom asymptote, llogKi=og10 Ki, H1=Hot ligand, H2=Hot Kd

Lower Bounds: none

Upper Bounds: none

Derived Parameters

Ki=10^(logKi)

EC50=10^(logKi)*(1+H1/H2)

Script Access

nlf_OneSiteCompFitKi(x,A1,A2,logKi,H1,H2)

Function File

OneSiteCompFitKi.fdf

Category

Binding