32.1.174 OneSiteAlloModShift

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\[y = \frac{B_{max}\cdot x}{x+KdHot\cdot\frac{10^{logK_b}+Allo}{10^{logK_b}+10^{logalpha}\cdot Allo}}\]

Brief Description

One site binding with allosteric modulator shift.

Sample Curve

Parameters

Number: 5

Names: logalpha, logKb, KdHot, Allo, Bmax

Meanings: logalpha=log of cooperativity constant, logKb=log of equilibrium dissociation constant, KdHot=equilibrium dissociation constant of radioligand, Allo=allosteric modulator, Bmax=top asymptote

Lower Bounds: none

Upper Bounds: none

Derived Parameters

alpha=10^logalpha

Kb=10^logKb

Script Access

nlf_OneSiteAlloModShift(x,logalpha,logKb,KdHot,Allo,Bmax)

Function File

OneSiteAlloModShift.fdf