32.1.166 NoncompetitiveInhibition

Function

\[V_{0}=\frac{V_{\max}}{\frac{K_{m}}{S}+1}\]

\[y=\frac{V_{0}}{2E}\left(E-x-K_{i}+\sqrt{\left(E-x-K_{i}\right)^{2}+4EK_{i}}\right)\]

Brief Description

Tight-binding noncompetitive inhibition model for high-affinity inhibitors.

Sample Curve

Parameters

Number: 5

Names: Vmax, Km, Ki, E, S Meanings: none

Lower Bounds: Vmax > 0, Km > 0, Ki > 0, E > 0 , S (none)

Upper Bounds: none

Script Access

nlf_NoncompetitiveInhibition(x,Vmax,Km,Ki,E,S)

Function File

NoncompetitiveInhibition.fdf

Category

Enzyme Kinetics 2