32.1.155 MixedInhibition
Contents
Function
\[V_{0}=\frac{V_{\max}}{\frac{K_{m}}{S}+1} \qquad K_{app}=\frac{K_{i}\left(\frac{s}{K_{m}}+1\right)}{1+\frac{s}{\alpha K_{m}}}\]
Brief Description
Tight-binding mixed-model inhibition for high-affinity inhibitors.
Sample Curve
Parameters
Number: 6
Names: Vmax, Km, Ki, alpha, E, S
Meanings: none
Lower Bounds: Vmax > 0, Km > 0, Ki > 0, alpha > 0, E > 0 , S (none)
Upper Bounds: none
Script Access
nlf_MixedInhibition(x,Vmax,Km,Ki,alpha,E,S)
Function File
MixedInhibition.fdf
Category
Enzyme Kinetics 2