32.1.101 GaddumSchildShiftLog

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\(y =A_1+\frac{A_2 - A_1}{10^{p(\text{LogEC}-x)} + 1} \)
\(\text{where} \; \text{LogEC} = \text{LogEC50} + \text{log}10\left(\left(\frac{B}{10^{-pA2}}\right)^{\text{SchildSlope}} + 1\right) \)

Brief Description

Gaddum/Schild EC50 shift with log(X)

Sample Curve

Parameters

Number: 7

Names:LogEC50, B, pA2, SchildSlope, A1, A2, p

Meanings: LogEC50=Logarithm of EC50, B=Antagonist concentration, pA2=Negative logarithm of antagonist concentration for EC50 shift by 2, SchildSlope=Slope for competitive inhibition, A1=Bottom asymptote, A2=Top asymptote, p=Hill slope

Lower Bounds: none

Upper Bounds: none

Derived Parameters

EC50=10^(LogEC50)

Antag2=10^(-pA2)

Script Access

nlf_GaddumSchildShiftLog(x,LogEC50,B,pA2,SchildSlope,A1,A2,p)

Function File

GaddumSchildShiftLog.fdf