32.1.100 GaddumSchildShift

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\[y = Bt + \frac{Tp-Bt}{1+\left(\left(\left(\frac{B}{10^{-p}}\right)^{SS}+1\right)\left(\frac{EC50}{x}\right)\right)^{HS}} \]

Brief Description

Gaddum/Schild EC50 shift for x is concentration.

Sample Curve

Parameters

Number: 7

Names: Bt, Tp, EC50, HS, SS, B, p

Meanings: Bt=lower plateau, Tp=Tpupper plateau, EC50=concentration in halfway, HS=Hill slope, SS=schild slope, B=antagonist concentration, p=negative logarithm of A2

Lower Bounds: none

Upper Bounds: none

Derived Parameters

logEC50=log(EC50)

logA2=-p

Script Access

nlf_GaddumSchildShift(x,Bt,Tp,EC50,HS,SS,B,p)

Function File

GaddumSchildShift.fdf