32.1.53 DoseRespShift

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\(y =A_1 + \frac{A_2 - A_1}{10^{p(\text{LogEC50 - x})+1}} \)
\(\text{where LogEC50 = LogECF} - \frac{\text{log10}(F/(100-F))}{p} \)

Brief Description

Dose-response curve with variable Hill slope and EC50 shift by ratio.

Sample Curve

Parameters

Number: 5

Names: LogEC50, ratio, A1, A2, p

Meanings: LogEC50=Logarithm of EC50 for agonist, ratio=Ratio of EC50 for inhibitor to agonist alone, A1=Bottom asymptote, A2=Top asymptote, p=Hill slope

Lower Bounds: none

Upper Bounds: none

Derived Parameters

EC50=10^LogEC50

Script Access

nlf_DoseRespShift(x,LogEC50,ratio,A1,A2,p)

Function File

DoseRespShift.fdf