32.1.51 DoseRespAbsIC50

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\(y =A_1 + \frac{A_2 - A_1}{10^{p(\text{LogIC50} - x) + \text{log}10((A_2 - A_1)/(A_{50} - A_1)-1)}+1} \)
\(\text{where } A_{50} = (B + A_2)/2 \)

Brief Description

Dose-response curve with variable Hill slope and absolute IC50.

Sample Curve

Parameters

Number: 5

Names: A1, A2, LogIC50, p, B

Meanings: A1=Bottom asymptote, A2=Top asymptote, LogIC50=Logarithm of concentration for response at half between top and baseline, p=Hill slope, B=Maximally inhibited response

Lower Bounds: none

Upper Bounds: none

Derived Parameters

IC50=10^LogIC50

Script Access

nlf_DoseRespAbsIC50(x,A1,A2,LogIC50,p,B)

Function File

DoseRespAbsIC50.fdf