32.1.22 BiphasicConcentration

Contents

Function

\[y = Bt+\frac{(Tp-Bt)\cdot p}{1+(\frac{EC501}{x})^{s1}}+\frac{(Tp-Bt)(1-p)}{1+(\frac{EC502}{x})^{s2}} \]

Brief Description

Fit the sum of two stimulatory dose response curves or two inhibitory dose response curve.

Sample Curve

BiphasicConcentration.png

Parameters

Number: 7

Names: Bt, Tp, EC501, EC502, s1, s2, p

Meanings: Bt= plateau at left end of curve, Tp=plateau at right end of curve, EC501=concentration at half-maximal, EC502=concentration at half-maximal, s1=Hill slope, s2=Hill slope, p=proportion of maximal response

Lower Bounds: p>0

Upper Bounds: p<1

Script Access

nlf_BiphasicConcentration(x,Bt,Tp,EC501,EC502,s1,s2,p)

Function File

BiphasicConcentration.fdf

Category

Dose Response