32.1.7 Assoc1conc

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\(y = \frac{L B_{\text{max}}}{L + K_{\text{off}} / K_{\text{on}}} \left(1 - e^{-(L K_{\text{on}} + K_{\text{off}})x}\right) \)
\(\text{where } L = \text{Hotnm} \times 1\text{E}-9 \)

Brief Description

A radioligand binding model used to determine the association rate constant of a ligand.

Sample Curve

Parameters

Number: 4

Names: Koff, Kon, Hotnm, Bmax

Meanings: Koff=dissociation rate constant, Kon=association rate constant, Hotnm=radioligand concentration in nM, Bmax=max binding capacity

Lower Bounds: none

Upper Bounds: none

Derived Parameters

nM_to_M=1e-09

Script Access

nlf_Assoc1conc(x,Koff,Kon,Hotnm,Bmax)

Function File

Assoc1conc.fdf