32.1.5 AllostericShift

1 Function
2 Brief Description
3 Sample Curve
4 Parameters
5 Derived Parameters
6 Script Access
7 Function File
8 Category

Function

\(y = Bt+\frac{Tp-Bt}{1+\left(\frac{EC50\cdot A}{x}\right)^s} \)

\(where \space A = \frac{B+KB}{alpha\cdot B+KB} \)

Brief Description

Allosteric EC50 shift when X is concentration or dose.

Sample Curve

Parameters

Number: 7

Names: B, KB, alpha, Bt, Tp, EC50, s

Meanings: B=modulator concentration, KB=equilibrium dissociation constant, alpha=ternary complex constant, Bt=bottom asymptote, Tp=top asymptote, EC50=agonist concentration at half maximal, s=Hill slope

Lower Bounds: none

Upper Bounds: none

Derived Parameters

logKB=log(KB)

logEC50=log(EC50)

logAlpha=log(alpha)

Script Access

nlf_AllostericShift(x,B,KB,alpha,Bt,Tp,EC50,s)

Function File

AllostericShift.fdf